Master/PhD thesis in Biophysics and Biophysical Chemistry
Structures and Functions of Native Cell Membranes Probed in Two-Dimensions
The primary goal of the project is to translate three-dimensional cells into two-dimensional
films by use of ultrathin, biopolymer interlayers, which provides with unique
advantages for quantitative characterization of their structures and functions.
Currently, we have several target systems, including: plasma membrane extracts
from cells that express engineered gap junction proteins (within the BMBF
project “Connexone”), cell membranes of
human red blood cells infected by Plasmodium falciparum (collaboration
with Prof. M. Lanzer, Inst. Parasitol.). The combination of the former system and
sold-based device is promising for biosensor applications, while the latter
opens a possibility to probe the local structures of cytoplasmic space of
infected red blood cells.
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