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Surface Science & Analytics - Prof. (apl.) Dr. Michael Zharnikov

Single-strand DNA films

Surface-bound ssDNA: properties, hybridization ability, and patterning

Anal. Chem. 83, 4288 (2011) and (2005) and Angew. Chem. Int. Ed. 51, 10303 (2012)

The structure and stability of single- and doublestranded DNA hybrids immobilized on gold are strongly affected by nucleotide-surface interactions. To systematically analyze the effects of these interactions, a set of model DNA hybrids was prepared in different conformations and studied systematically using a suitable combination of complementary experimental techniques. In another project, we developed a universal two-step procedure to fabricate mixed ssDNA/OEG-AT monolayers and patterns on gold substrates (OEG-AT: oligo(ethylene glycol) substituted alkanethiol). The procedure is based on promoted exchange reaction and relies on commercially available compounds—making it easily accessible—and is highly flexible in terms of the composition of the mixed monolayers, as well as the size and shape of the DNA patterns that can be formed on the OEG-AT background.
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